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      您的位置: 首頁>產品中心>Large Na?ve VHH library> Phage display based Na?ve VHH Library from llama
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      Large Na?ve VHH library

      Phage display based Na?ve VHH Library from llama

      Category: Large Na?ve VHH library

      Product overview Documents References FAQ

      The preparation of single domain antibody libraries starting from lymphocytes recovered from immunized members of the Camelidae enables to collect binders that underwent somatic maturation. However, the time and costs necessary to prepare a library for each new antigen may urge to look for alternatives such as those offered by large one-pot libraries. 


      Here we constructed five large na?ve libraries using PBMCs  from 20 healthy nonimmunized llamas.The library consists of 1010 individual transformants with more than 90 % unique sequences and  the positive insert ratio was more than 99.99%. We leverage this established library along with our advanced screening platform to extend the epitope coverage and help clients find the optimal monoclonal antibody candidates Despite the lack of somatic maturation, the selection based on phage display allowed to isolate from such na?ve libraries VHHs with affinity in the subnanomolar range and suitable for the standard immune applications. 

      Cat#librarypositive insert ratiolibrary size
      LlaSDAb-01PPhage display100%3.1X109
      LlaSDAb-02PPhage display100%5.7×109
      LlaSDAb-03PPhage display100%4.8X109

      LlaSDAb-04P

      Phage display100%3.0×109





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      If you want to sell VHH on our platform, please contact us !

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      13551086942

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      service@nb-biolab.com

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      企業郵箱:service@nb-biolab.com


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